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There may be concurrent abnormal muscle tone, either hypotonia or rigidity. Hyperpronation of the upper extremity may be seen when attempting to maintain an extended posture. The pathophysiology of chorea (as for ballismus) is unknown; movements may be associated with lesions of the contralateral sub- thalamic nucleus, caudate nucleus, putamen, and thalamus. One model - 72 - Chromesthesia C of basal ganglia function suggests that reduced basal ganglia output to the thalamus disinhibits thalamic relay nuclei leading to increased excitability in thalamocortical pathways which passes to descending motor pathways resulting in involuntary movements. Recognized causes of chorea and choreoathetosis are many, including: ● Hereditary: Huntington’s disease (HD) Dentatorubropallidoluysian atrophy (DRPLA) Neuroacanthocytosis Benign hereditary chorea Paroxysmal dyskinesias: paroxysmal kinesigenic choreoathetosis (PKC) and paroxysmal dystonic choreoathetosis (PDC) ● Sporadic: Drugs: levodopa therapy in later stages of idiopathic Parkinson’s disease Pregnancy: chorea gravidarum Hyperthyroidism Systemic lupus erythematosus (SLE) Sydenham’s chorea (post-infectious, rheumatic chorea, St. Vitus dance, PANDAS) Polycythemia rubra vera (hyperviscosity) AIDS Hyperosmolality (hyperglycemia, hypernatremia) CNS tumor Multiple sclerosis (rare) Variant Creutzfeldt-Jakob disease “Senile chorea” (diagnosis of exclusion, especially of HD) Where treatment is necessary, antidopaminergic agents, such as dopamine receptor antagonists (e. Chronic neuroleptic use may also cause chorea, but these movements are repetitive and predictable, unlike “classic” chorea. Advances in Clinical Neuroscience & Rehabilitation 2003; 3(4): 19-20 Sawle G. Journal of Neurology 1998; 245: 709-716 Cross References Athetosis; Ballism, Ballismus; Dyskinesia; Hypotonia, Hypotonus; Milkmaid’s grip; PseudoChoreoathetosis; Rigidity; Trombone tongue Chromesthesia - see SYNESTHESIA - 73 - C Chvostek’s Sign Chvostek’s Sign Chvostek’s sign is contraction of facial muscles provoked by lightly tap- ping over the facial nerve as it crosses the zygomatic arch. Chvostek’s sign is observed in hypocalcemic states, such as hypoparathyroidism and the respiratory alkalosis associated with hyperventilation. There may be concurrent posturing of the hand, known as main d’accoucheur for its resemblance to the posture adopted for manual delivery of a baby. The pathophysiology of this mechanosensitivity of nerve fibers is uncertain, but is probably related to increased discharges in central pathways. Although hypocalcemia might be expected to impair neuromuscular junction transmission and excitation-contraction coupling (since Ca2+ ions are required for these processes) this does not in fact occur.

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Other pathologies include pontine hemorrhage and central pontine myelinolysis. Bilateral ventral midbrain and internal capsule infarcts can produce a similar picture. The locked-in syndrome may be mistaken for abulia, akinetic mutism, coma, and catatonia. Neurology 1971; 21: 459-478 Cross References Abulia; Akinetic mutism; Blinking; Catatonia; Coma; Pathological crying, Pathological laughter Lockjaw - see TRISMUS Logoclonia Logoclonia is the tendency for a patient to repeat the final syllable of a word when speaking; hence it is one of the reiterative speech disor- ders (cf. It may be described as the festinating rep- etition of individual phonemes. Logoclonia is an indicator of bilateral brain injury, usually involv- ing subcortical structures, and may be seen in the late stages of demen- tia of Alzheimer type (but not in semantic dementia). Cross References Echolalia; Festination, Festinant gait; Palilalia; Perseveration - 187 - L Logopenia Logopenia Logopenia is a reduced rate of language production, due especially to word finding pauses, but with relatively preserved phrase length and syntactically complete language, seen in aphasic syndromes, such as primary progressive aphasia. Cross References Aphasia Logorrhea Logorrhea is literally a flow of speech, or pressure of speech, denoting an excessive verbal output, an abnormal number of words produced during each utterance. The term may be used of the output in the Wernicke/posterior type of aphasia, or of an output which superficially resembles Wernicke aphasia but in which syntax and morphology are intact, rhythm and articulation are usually normal, and paraphasias and neologisms are few. Moreover comprehension is better than antic- ipated in the Wernicke type of aphasia. Patients may be unaware of their impaired output (anosognosia) due to a failure of self-monitoring. Logorrhea may be observed in subcortical (thalamic) aphasia, usually following recovery from lesions (usually hemorrhage) to the anterolateral nuclei. Similar speech output may be observed in psychi- atric disorders, such as mania and schizophrenia. New England Journal of Medicine 1992; 326: 531-539 Cross References Aphasia; Delirium; Echolalia; Jargon aphasia; Wernicke’s aphasia Long Tract Signs - see UPPER MOTOR NEURONE (UMN) SYNDROME “Looking Glass Syndrome” - see MIRROR AGNOSIA Lower Motor Neurone (LMN) Syndrome A lower motor neurone (LMN) syndrome constitutes a constellation of motor signs resulting from damage to lower motor neurone path- ways, i. Following the standard order of neurological examination of the motor system, the signs include: ● Appearance: muscle wasting; fasciculations (or “fibrillations”) may be observed or induced, particularly if the pathology is at the level of the anterior horn cell - 188 - Lower Motor Neurone (LMN) Syndrome L ● Tone: reduced tone (flaccidity, hypotonus), although this may simply reflect weakness ● Power: weakness, often marked; depending on the precise patholog- ical process, weakness often affects both flexor and extensor muscles equally (although this is not always the case) ● Coordination: depending on the degree of weakness, it may not be possible to comment on the integrity or otherwise of coordination in LMN syndromes; in a pure LMN syndrome coordination will be normal ● Reflexes: depressed (hyporeflexia) or absent (areflexia); plantar responses are flexor. It is often possible to draw a clinical distinction between motor symptoms resulting from lower or upper motor neurone pathology and hence to formulate a differential diagnosis and direct investiga- tions accordingly.

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Jarock, 40 years: A basic examination should include measurement of respiratory rate, pulse, and blood pressure; brief assessment of the level of consciousness and pupillary responses; and examination of the head, chest, abdomen, pelvis and limbs for obvious signs of (c) trauma. He had been formed by Nicoladani in 1882, when he attached obliged to rewrite the whole work and to arrange the peronei to the tendo achillis in a patient with the various subjects according to their etiology talipes calcaneus. The classic example, and probably the most frequently observed, is abducens nerve palsy (unilateral or bilateral) in the context of raised intracranial pressure, presumed to result from stretching of the nerve over the ridge of the petrous temporal bone.

Dennis, 36 years: In a double-blind placebo- controlled study, lamotrigine resulted in a decrease in seizure frequency of > 50% in 33% of patients vs. The mainstay of pharmacologic therapy is oral pyridostigmine, with occasional patients also benefitting from ephedrine. These signs should be documented serially to assess any progres- sion of coma.

Tom, 31 years: Physical therapists have developed an extensive battery of diagnostic as- sessment tools and therapeutic modalities. Prolonged seem to be tolerant of hypoxia and resuscitation should be attempts in such patients are rarely successful and are continued for longer than in adults associated with a high incidence of cerebral damage. Flexion and extension correction was not generally taken into account, and only simple varus correction was performed.

Topork, 63 years: London: BMJ Publishing, 1997: 253-282 Cross References Cover tests; Esophoria; Exophoria; Heterotropia; Hyperphoria; Hypophoria Heterotropia Heterotropia is a generic term for manifest deviation of the eyes (man- ifest strabismus; cf. Far from challenging medical authority, men’s health promoters urged men to submit themselves to it on a greater scale than ever before. Overt research I believe researchers should be open and honest about who they are and what they’re doing.

Ramirez, 26 years: Depending of the type of plasmid, prokaryotic; DNA (Deoxyribonucleic acid); Enzymes; replication may involve integration into the bacterial chromo- Genetic regulation of eukaryotic cells; Genetic regulation of some or can be independent. You should therefore be planning ways of incorporating some of the techniques described in the next section. Step Five: Search for Other Past or Present Mental or Physical Problems.

Alima, 38 years: Serious illnesses of one family member, especially debilitating diseases, can decimate family savings. Philip Candy identified in the literature about 100 traits Self directed learning associated with self direction, which he synthesised as the ability x Organising teaching and learning so that to be methodical and disciplined; logical and analytical; learning is within the learners’ control collaborative and interdependent; curious, open, creative, and x A goal towards which learners strive so that they become able to accept responsibility for their motivated; persistent and responsible; confident and competent own learning at learning; and reflective and self aware. In the more concise representation at the top, hydrogen atoms attached to carbon are omitted, and the carbon–oxygen double bond in the ketone is drawn with a double line.

Hurit, 24 years: In The Treatment of until the time of his death (1959), he was distin- Pes Cavus (1921), he analyzed the muscle imbal- guished service professor emeritus of the univer- ance that produced claw foot and advocated the 319 Who’s Who in Orthopedics correction of the severe skeletal deformity by of the wrist and the fingers. After she bought a cane at a local drug store and carried it to her next appointment, the physician noticed it—he adjusted the cane’s height and told her how best to use it. This is very hard to avoid but if it happens too frequently you will soon find all conversation is channelled in your direction and there will be no interaction between the students.

Hamil, 46 years: Jane Rissler of the Union of Con- cerned Scientists says, “We know very little about the long-term impacts of genetically engineered food, so as a general matter, they should be subject to more scrutiny. After people receive equipment, they must be trained to use it, espe- cially on how to avoid falls and other injuries. You should spend at least a few days doing a bit of research for the big day.

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